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Fig. 2 CytoConverter output from a cancer cell line. The top panel shows a screenshot of CytoConverter as applied to the karyotype of the cell line AML-193. The output produced by our web tool is under “Text Result,” wherein the sample is referred to as “sample_1” by default. The bottom panel shows the results from microarray-based copy number analysis of AML-193, as performed in Barretina et al. and visualized using cBioPortal. In cBioPortal output, red indicates gains, blue indicates losses, and a darker color indicates a larger deviation from normal (i.e., a “deeper” deletion or higher-level amplification). Note that cBioPortal reports Y as having been lost, though the cell line is derived from a male patient with only X chromosomes constitutionally and therefore the Y chromosome was not present in the sample.

Wang, J.; LaFramboise, T. (2019). "CytoConverter: A web-based tool to convert karyotypes to genomic coordinates". BMC Bioinformatics 20: 467. doi:10.1186/s12859-019-3062-4. 

2019

Wang, J.; LaFramboise, T.

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